Management of Severe and Severe/Complicated Clostridoides difficile Infection Using Sequential Fecal Microbiota Transplant by Retention Enema. (21st January 2021)

• Record Type: Journal Article
• Authors: Rupawala, Abbas Hatim; Gachette, Darrel; Bakhit, Mena; Jimoh, Lanre; Kelly, Colleen R
• Is Part Of: Clinical infectious diseases. Volume 73:Number 4(2021)
• Page Start: 716
• Page End: 719
• Publication Date: 2021-01-21
• Subjects: fecal microbiota transplant -- FMT -- severe C. difficile infection -- complicated C. difficile infection -- enema; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciab041
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: We evaluated serial fecal microbiota transplant (FMT) by retention enema in patients with severe or severe/complicated Clostridoides difficile infection (CDI) unresponsive to at least 48 hours of standard antibiotic therapy. Of the 15 patients included, despite initial improvement in most patients, only 5 patients sustained cure at 30 days, and serious adverse events occurred in 4 patients.