Second transurethral resection for high-risk non-muscle invasive bladder cancer patients: a propensity score matched analysis. (23rd April 2020)

• Record Type: Journal Article
• Authors: Matsushita, Yuto; Watanabe, Kyohei; Watanabe, Hiromitsu; Tamura, Keita; Motoyama, Daisuke; Ito, Toshiki; Sugiyama, Takayuki; Otsuka, Atsushi; Miyake, Hideaki
• Is Part Of: Japanese journal of clinical oncology. Volume 50:Number 6(2020)
• Page Start: 718
• Page End: 721
• Publication Date: 2020-04-23
• Subjects: high-risk non-muscle invasive bladder cancer -- second TUR -- propensity score matched analysis -- prognosis; Oncology -- Periodicals; Cancer -- Periodicals; 616.994005
• DOI: 10.1093/jjco/hyaa041
• Languages: English
• ISSNs: 0368-2811

Abstract

Abstract: Objectives: Second transurethral resection is recommended for patients diagnosed with high-risk non-muscle invasive bladder cancer; however, there have been several studies showing conflicting findings regarding the advantage of second transurethral resection. The objective of this study was to investigate the prognostic significance of second transurethral resection using propensity score matched analysis. Patients and Methods: This study retrospectively included 164 consecutive patients who underwent initial transurethral resection and were diagnosed with high-risk non-muscle invasive bladder cancer. Of these, 56 subsequently received second transurethral resection, and the remaining 108 underwent initial transurethral resection alone. Results: After adjusting patient variables by propensity score matching, 44 patients were included in each group. There was no significant difference in recurrence-free, progression-free or overall survival between these two groups. Conclusions: These findings suggested no significant impact of second transurethral resection on the prognosis of high-risk non-muscle invasive bladder cancer patients; therefore, it may be necessary to perform a reassessment focusing on the indication for second transurethral resection by conducting a large-scale prospective study. Abstract : We investigated the prognostic significance of second transurethral resection for patients with high-risk non-muscle invasive bladder cancer using propensity score matched analysis. There were no significant impacts on oncological outcomes.