Inflammatory Biomarkers Do Not Differ Between Persistently Seronegative vs Seropositive People With HIV After Treatment in Early Acute HIV Infection. (26th August 2020)

• Record Type: Journal Article
• Authors: Cai, Catherine W; Pinyakorn, Suteeraporn; Kroon, Eugène; de Souza, Mark; Colby, Donn J; Pankam, Tippawan; Pattanachaiwit, Supanit; Ubolyam, Sasiwimol; Rupert, Adam; Lallemand, Perrine; Dewar, Robin; Highbarger, Helene C; Ananworanich, Jintanat; Vasan, Sandhya; Sereti, Irini
• Is Part Of: Open forum infectious diseases. Volume 7:Number 9(2020)
• Publication Date: 2020-08-26
• Subjects: AIDS -- chronic inflammation -- coagulopathy -- HIV -- viral reservoir; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofaa383
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Persistent viral activity may cause enduring seropositivity and inflammation in treated people with HIV (PWH). We compared inflammatory biomarkers between early treated PWH who remained seronegative or seroconverted and found similar levels of D-dimer, soluble cluster of differentiation 14, C-reactive protein, and interleukin-6, indicating that seronegativity does not affect chronic inflammation in early treated PWH.