CYTOCON: The manually curated database of human in vivo cell and molecule concentrations. (6th October 2022)

• Record Type: Journal Article
• Authors: Leonov, Vladislav; Mogilevskaya, Ekaterina; Gerasimuk, Elita; Gizzatkulov, Nail; Demin, Oleg
• Is Part Of: CPT: pharmacometrics & systems pharmacology. Volume 12:Number 1(2023)
• Page Start: 41
• Page End: 49
• Publication Date: 2022-10-06
• Subjects: Pharmacokinetics -- Periodicals; Pharmacology -- Periodicals; Pharmacokinetics; Periodicals; 615.05
• DOI: 10.1002/psp4.12867
• Languages: English
• ISSNs: 2163-8306

Abstract

Abstract: Cell and cYTOkine CONcentrations DataBase (CYTOCON DB) is a project undertaken by the InSysBio team and aimed at the development of a database that allows collecting, processing, and visualizing publicly available in vivo human data on baseline concentrations of cells, cytokines, chemokines, and other molecules. Besides manual curation, an important feature of CYTOCON is that most values found in papers are converted from a huge variety of original units (i.e., mg/ml and number of cells per mm 2 of biopsy surface section) to unified units: "pM" for cytokine and "kcell/L" for cell concentration. These features of the database can help researchers facilitate the creation and calibration of quantitative systems pharmacology (QSP) models. Possible applications can be: estimation of the average value or variability of the cell, cytokine or chemokine concentrations for patient groups with different characteristics, such as age, gender, disease severity, disease subtype, etc.; and analysis of correlations among the cell, cytokine, or chemokine concentrations in patients with different characteristics, such as severity of the disease.