Fibrin-Associated Diffuse Large B Cell Lymphoma Found on Revision Arthroplasty of the Knee. Issue 11 (November 2021)

• Record Type: Journal Article
• Authors: Hall, Jordan; Kampfer, Craig; Williams, Ned; Osswald, Michael; Bishop, Bradie; Hall, Misty; Alderete, Joseph
• Is Part Of: Southern medical journal. Volume 114:Issue 11(2021)
• Publication Date: 2021-11
• Subjects: fibrin-associated (Epstein-Barr virus–positive) diffuse large B cell lymphoma (FA-DLBCL) -- foreign body -- multidisciplinary approach -- non-Hodgkin lymphoma -- orthopedic metallic implant; Medicine -- Periodicals; 610.5
• DOI: 10.14423/SMJ.0000000000001321
• Languages: English
• ISSNs: 0038-4348

Abstract

Abstract : Abstract: Fibrin-associated diffuse large B cell lymphoma (FA-DLBCL) is a rare Epstein-Barr viruspositive B cell lymphoma that is nonmass-forming, does not directly produce symptoms, and is incidentally discovered on histological examination of tissues excised for other reasons. Despite overlap in morphologic and immunophenotypic features with aggressive B cell neoplasms, FA-DLBCL shows an excellent clinical outcome, even with surgical excision alone. We report an extremely rare occurrence of FA-DLBCL found in association with a metallic implant on revision arthroplasty of the knee. This report also illustrates the need for an integrated multidisciplinary approach for accurate diagnosis and avoidance of overtreatment. Abstract : Fibrin-associated diffuse large B cell lymphoma is a rare non-Hodgkin lymphoma that is nonmass forming, does not directly produce symptoms, and is discovered incidentally on histological examination of tissues excised for other reasons. This article illustrates the need for a multidisciplinary approach to a patient with fibrin-associated diffuse large B cell lymphoma incidentally identified on revision arthroplasty of the knee.