Associations of body mass index and weight change with circulating levels of high‐sensitivity C‐reactive protein, proinflammatory cytokines, and adiponectin among breast cancer survivors. Issue 1 (19th May 2022)

• Record Type: Journal Article
• Authors: Cho, Hyun Jeong; Song, Sihan; Kim, Zisun; Youn, Hyun Jo; Cho, Jihyoung; Min, Jun Won; Kim, Yoo Seok; Choi, Sang‐Woon; Lee, Jung Eun
• Is Part Of: Asia-Pacific journal of clinical oncology. Volume 19:Issue 1(2023)
• Page Start: 113
• Page End: 125
• Publication Date: 2022-05-19
• Subjects: body mass index -- breast cancer survivors -- inflammatory markers -- Korea -- weight change; Oncology -- Pacific Area -- Periodicals; Cancer -- Treatment -- Pacific Area -- Periodicals; Cancer -- Pacific Area -- Periodicals; Cancer -- Treatment -- Periodicals; 616.9940095
• DOI: 10.1111/ajco.13779
• Languages: English
• ISSNs: 1743-7555

Abstract

Abstract: Aim: This study examined the associations of body mass index (BMI) and weight change with inflammatory markers among breast cancer survivors in Korea. Methods: A total of 495 women were included who had been diagnosed with primary breast cancer and survived for at least 6 months since the surgery. Information on the body weight and height of the participants was collected both at the study enrollment and diagnosis. The plasma levels of inflammatory markers were measured, including high‐sensitivity C‐reactive protein, interleukin (IL)‐6, IL‐8, tumor necrosis factor‐α, and adiponectin. A summary z‐score was calculated by summing up the z‐scores of each biomarker. The least‐square means and 95% confidence intervals (CIs) were calculated using a generalized linear model and odds ratios (ORs) and 95% CIs for the elevated levels of inflammatory markers with a multivariate logistic regression model. Results: Participants with a BMI ≥27.5 kg/m 2 at the study enrollment and at diagnosis were significantly associated with elevated summary z‐scores compared to those with a BMI < 23 kg/m 2 ; the ORs (95% CIs) were 5.42 (2.15–13.71) for current BMI and 3.66 (1.68–7.98) for BMI at diagnosis, respectively. Additionally, a weight loss > 5% since diagnosis was associated with a lower prevalence of high summary z‐scores; the OR (95% CI) was .20 (.08–.52) compared to a stable weight. Conclusions: A high BMI at diagnosis and current BMI with a greater degree were associated with unfavorable levels of inflammatory markers among breast cancer survivors. Additionally, weight loss since diagnosis was inversely associated with these markers. Graphical Abstract: Among around 400 Korean breast cancer survivors, we found that a high BMI was associated with unfavorable levels of inflammatory markers. High BMI at study entry, more so than at diagnosis, showed a strong association with the summary z‐score for inflammatory markers.