Metallo-β-lactamase, extended spectrum β-lactamase and mcr-1 gene as major therapeutic challenges. Issue 1 (2nd January 2022)

• Record Type: Journal Article
• Authors: Talebi, Ghazaleh; Hashemi, Ali
• Is Part Of: Reviews in medical microbiology. Volume 33:Issue 1(2022)
• Page Start: e40
• Page End: e47
• Publication Date: 2022-01-02
• Subjects: carbapenems -- cephalosporins -- extended spectrum β-lactamase -- mcr-1 gene -- metallo-β-lactamase; Medical microbiology -- Periodicals; Medical microbiology; Periodicals; 616.904105
• DOI: 10.1097/MRM.0000000000000249
• Languages: English
• ISSNs: 0954-139X

Abstract

Abstract : Antibiotic resistance is a major problem worldwide. There are different types of resistance specially in Gram-negative bacteria. Emergence of carbapenem resistance in Enterobacteriaceae, Pseudomonas, Acinetobacter and Klebsiella spp. is a main public health problem in the world. The β-lactamases are classified according to their functional similarities or molecular structures. There are two various families of β-lactamases that are found in bacteria. One of the causes of bacterial resistance is failure in treatment. Metallo-β-lactamases (MBLs) are associated with serine protease that are categorized in Ambler class B. MBL gene transfer is horizontally by mobile genetic elements. Extended spectrum β-lactamases are the main class of β-lactamases and show resistance to cephalosporins. In this review, we focus on special resistance genes and their origin. Also, we try to demonstrate new treatments for resistant bacteria.