Extramedullary Hematopoiesis in the Dura Mater During Treatment of a CNS Embryonal Tumor. Issue 8 (November 2021)

• Record Type: Journal Article
• Authors: Ganapathi, Shireen S.; Havard, Molly E.; Ferguson, Mark; Cole, Bonnie L.; Millard, Nathan E.; Vitanza, Nicholas A.
• Is Part Of: Journal of pediatric hematology/oncology. Volume 43:Issue 8(2021)
• Publication Date: 2021-11
• Subjects: extramedullary hematopoiesis (EMH) -- central nervous system (CNS) -- brain tumor -- granulocyte colony-stimulating factor -- chemotherapy; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0000000000001962
• Languages: English
• ISSNs: 1077-4114

Abstract

Abstract : Extramedullary hematopoiesis (EMH) is hematopoiesis occurring outside of the bone marrow. It has been reported to develop in abdominal organs or lymph nodes after chemotherapy. Here, the authors describe a patient with a localized central nervous system embryonal tumor who, during intensive chemotherapy, developed dural nodules. Biopsy revealed these nodules to be EMH. Without a pathologic diagnosis, this may have been considered disease progression, altering the patient's treatment plan. This report intends to serve as a reminder that EMH should be included in the differential diagnosis of suspicious lesions and highlights the importance of their biopsy because of potential management implications.