Metastatic Uterine Carcinosarcoma to the Orbit. Issue 6 (November 2021)

• Record Type: Journal Article
• Authors: Qureshi, Sana; Patel, Nimesh A.; Patel, Nish; Ghassibi, Mark P.; Tse, David T.; Dubovy, Sander R.
• Is Part Of: Ophthalmic plastic and reconstructive surgery. Volume 37:Issue 6(2021)
• Publication Date: 2021-11
• Subjects: Eye -- Surgery -- Periodicals; Ophthalmic plastic surgery -- Periodicals; Reconstructive Surgical Procedures -- Periodicals; Ophthalmologic Surgical Procedures -- Periodicals; Ophthalmology -- Periodicals; Surgery -- Periodicals; 617.70592
• DOI: 10.1097/IOP.0000000000002006
• Languages: English
• ISSNs: 0740-9303

Abstract

Abstract : Metastases of solid tumors to the eye and ocular adnexa are rare. Herein, the authors describe the clinical, histologic, and immunohistochemical findings of a patient with a history of adenocarcinoma of the colon and a uterine carcinosarcoma (malignant mixed Müllerian tumor) who presented with proptosis and decreased vision. Positive staining with PAX-8, p16 and negative reaction for CK20 and CDX2 helped to establish the uterine origin of the metastasis. This rare case demonstrates the utility of immunohistochemical probes, especially in patients with a complex oncological history, where multiple primary sources of the metastasis are in the differential diagnosis. Abstract : Immunohistochemical stains are critical in distinguishing the histologic origin of an orbital mass in a patient with a complex oncological history presenting with proptosis and decreased vision.