Characteristics of the Ontario Neurodegenerative Disease Research Initiative cohort. Issue 1 (30th March 2022)

• Record Type: Journal Article
• Authors: Sunderland, Kelly M.; Beaton, Derek; Arnott, Stephen R.; Kleinstiver, Peter; Kwan, Donna; Lawrence‐Dewar, Jane M.; Ramirez, Joel; Tan, Brian; Bartha, Robert; Black, Sandra E.; Borrie, Michael; Brien, Donald; Casaubon, Leanne K.; Coe, Brian C.; Cornish, Benjamin; Dilliott, Allison A.; Dowlatshahi, Dar; Finger, Elizabeth; Fischer, Corinne; Frank, Andrew; Fraser, Julia; Freedman, Morris; Greenberg, Barry; Grimes, David A.; Hassan, Ayman; Hatch, Wendy; Hegele, Robert A.; Hudson, Christopher; Jog, Mandar; Kumar, Sanjeev; Lang, Anthony; Levine, Brian; Lou, Wendy; Mandzia, Jennifer; Marras, Connie; McIlroy, William; Montero‐Odasso, Manuel; Munoz, David G.; Munoz, Douglas P.; Orange, Joseph B.; Park, David S.; Pasternak, Stephen H.; Pieruccini‐Faria, Frederico; Rajji, Tarek K.; Roberts, Angela C.; Robinson, John F.; Rogaeva, Ekaterina; Sahlas, Demetrios J.; Saposnik, Gustavo; Scott, Christopher J.M.; Seitz, Dallas; Shoesmith, Christen; Steeves, Thomas D.L.; Strong, Michael J.; Strother, Stephen C.; Swartz, Richard H.; Symons, Sean; Tang‐Wai, David F.; Tartaglia, Maria Carmela; Troyer, Angela K.; Turnbull, John; Zinman, Lorne; McLaughlin, Paula M.; Masellis, Mario; Binns, Malcolm A.;
• Other Names: Abrahao Agessandro investigator.; Adamo Sabrina investigator.; Berezuk Courtney investigator.; Black Alanna investigator.; Breen David P. investigator.; Bulman Dennis investigator.; Chen Ying investigator.; El‐Defrawy Sherif investigator.; Farhan Sali investigator.; Ghani Mahdi investigator.; Gonder John investigator.; Haddad Seyyed M. H. investigator.; Holmes Melissa investigator.; Huang Jeff investigator.; Leontieva Elena investigator.; Mandelcorn Efrem investigator.; Margolin Edward investigator.; Nanayakkara Nuwan investigator.; Ozzoude Miracle investigator.; Peltsch Alicia J. investigator.; Pollock Bruce investigator.; Raamana Pradeep investigator.; Rashkovan Natalie investigator.; Yanina investigator.; Southwell Alisia investigator.; Sujanthan Sujeevini investigator.; Tayyari Faryan investigator.; Van Ooteghem Karen investigator.; Woulfe John investigator.; Zamyadi Mojdeh investigator.; Zou Guangyong investigator.;
• Is Part Of: Alzheimer's & dementia. Volume 19:Issue 1(2023)
• Page Start: 226
• Page End: 243
• Publication Date: 2022-03-30
• Subjects: Alzheimer's disease -- amnestic mild cognitive impairment -- amyotrophic lateral sclerosis -- cerebrovascular disease -- cohort study -- dementia -- frontotemporal dementia spectrum disorder -- neurodegenerative disease -- Parkinson's disease; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1002/alz.12632
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Introduction: Understanding synergies between neurodegenerative and cerebrovascular pathologies that modify dementia presentation represents an important knowledge gap. Methods: This multi‐site, longitudinal, observational cohort study recruited participants across prevalent neurodegenerative diseases and cerebrovascular disease and assessed participants comprehensively across modalities. We describe univariate and multivariate baseline features of the cohort and summarize recruitment, data collection, and curation processes. Results: We enrolled 520 participants across five neurodegenerative and cerebrovascular diseases. Median age was 69 years, median Montreal Cognitive Assessment score was 25, median independence in activities of daily living was 100% for basic and 93% for instrumental activities. Spousal study partners predominated; participants were often male, White, and more educated. Milder disease stages predominated, yet cohorts reflect clinical presentation. Discussion: Data will be shared with the global scientific community. Within‐disease and disease‐agnostic approaches are expected to identify markers of severity, progression, and therapy targets. Sampling characteristics also provide guidance for future study design.