Neighborhood disadvantage and dementia incidence in a cohort of Asian American and non‐Latino White older adults in Northern California. Issue 1 (6th April 2022)

• Record Type: Journal Article
• Authors: Mobley, Taylor M.; Shaw, Crystal; Hayes‐Larson, Eleanor; Fong, Joseph; Gilsanz, Paola; Gee, Gilbert C.; Brookmeyer, Ron; Whitmer, Rachel A.; Casey, Joan A.; Mayeda, Elizabeth Rose
• Is Part Of: Alzheimer's & dementia. Volume 19:Issue 1(2023)
• Page Start: 296
• Page End: 306
• Publication Date: 2022-04-06
• Subjects: dementia -- incidence -- neighborhood disadvantage -- racial/ethnic disparities -- social determinants; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1002/alz.12660
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Introduction: Some evidence suggests that neighborhood socioeconomic disadvantage is associated with dementia‐related outcomes. However, prior research is predominantly among non‐Latino Whites. Methods: We evaluated the association between neighborhood disadvantage (Area Deprivation Index [ADI]) and dementia incidence in Asian American (n = 18, 103) and non‐Latino White (n = 149, 385) members of a Northern California integrated health care delivery system aged 60 to 89 at baseline. Race/ethnicity‐specific Cox proportional hazards models adjusted for individual‐level age, sex, socioeconomic measures, and block group population density estimated hazard ratios (HRs) for dementia. Results: Among non‐Latino Whites, ADI was associated with dementia incidence (most vs. least disadvantaged ADI quintile HR = 1.09, 95% confidence interval [CI] = 1.02–1.15). Among Asian Americans, associations were close to null (e.g., most vs. least disadvantaged ADI quintile HR = 1.01, 95% CI = 0.85–1.21). Discussion: ADI was associated with dementia incidence among non‐Latino Whites but not Asian Americans. Understanding the potentially different mechanisms driving dementia incidence in these groups could inform dementia prevention efforts.