Cigarettes smoking and androgen receptor-positive breast cancer. Issue 6 (November 2021)

• Record Type: Journal Article
• Authors: Pizzato, Margherita; Carioli, Greta; Rosso, Stefano; Zanetti, Roberto; Negri, Eva; La Vecchia, Carlo
• Is Part Of: European journal of cancer prevention. Volume 30:Issue 6(2021)
• Publication Date: 2021-11
• Subjects: androgen receptor -- breast cancer -- cigarette smoking; Cancer -- Prevention -- Periodicals; Neoplasms -- etiology -- Periodicals; Neoplasms -- prevention & control -- Periodicals; Cancer -- Prevention; Periodicals; 616.994052
• DOI: 10.1097/CEJ.0000000000000661
• Languages: English
• ISSNs: 0959-8278

Abstract

Abstract : Objectives: Cigarette smoking is related to higher levels of circulating androgens, but its association with androgen receptor (AR) status is still unaddressed. Methods: We analysed, with a case-only approach, smoking habits according to AR status in 112 cases of invasive female breast cancer, from the Piedmont Cancer Registry. We used a multivariate logistic regression model to estimate the odds ratio (OR) and the corresponding confidence interval (CI). Results: The OR of AR-positive breast cancer (versus AR-negative) for ever smokers (versus never) was 2.85 (95% CI 1.02–7.96). Conclusion: Smoking is related to AR-positive breast cancer.