Adult Diffuse Astrocytic and Oligodendroglial Tumors. Issue 5 (November 2021)

• Record Type: Journal Article
• Authors: Gestrich, Catherine K; Couce, Marta E; Cohen, Mark L
• Is Part Of: Neurosurgery. Volume 89:Issue 5(2021)
• Publication Date: 2021-11
• Subjects: Astrocytoma -- Diffuse midline glioma -- Fluorescence in Situ hybridization, Glioblastoma -- molecular diagnostics -- Next‐generation sequencing -- Oligodendroglioma; Nervous system -- Surgery -- Periodicals; 617.48005
• DOI: 10.1093/neuros/nyab042
• Languages: English
• ISSNs: 0148-396X

Abstract

Abstract : N/A: Infiltrating gliomas comprise the most common group of primary intraparenchymal brain tumors and present a level of complexity which requires careful integration of histopathology and molecular diagnostics for optimal therapy. To this end, the fourth edition of the World Health Organization (WHO) Classification of Tumors of the Central Nervous System (CNS) has been followed by a series of publications by cIMPACT‐NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy) incorporating molecular signatures to propose updated diagnostic categories in anticipation of the upcoming fifth edition of CNS tumor classification. Integration of histopathology, immunophenotyping, and molecular findings is profoundly changing the practice of diagnostic surgical neuropathology and enabling a more personalized approach to treating patients with gliomas.