MR‐Nucleomics: The study of pathological cellular processes with multinuclear magnetic resonance spectroscopy and imaging in vivo. (16th November 2022)

• Record Type: Journal Article
• Authors: Sun, Peng; Wu, Zhigang; Lin, Liangjie; Hu, Geli; Zhang, Xiaoxiao; Wang, Jiazheng
• Is Part Of: NMR in biomedicine. Volume 36:Number 2(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-11-16
• Subjects: cellular process -- clinical translation -- metabolite -- MRI -- MRS -- multinuclear; Nuclear magnetic resonance -- Periodicals; Magnetic Resonance Spectroscopy -- Periodicals; 574
• DOI: 10.1002/nbm.4845
• Languages: English
• ISSNs: 0952-3480

Abstract

Abstract: Clinical medicine has experienced a rapid development in recent decades, during which therapies targeting specific cellular signaling pathways, or specific cell surface receptors, have been increasingly adopted. While these developments in clinical medicine call for improved precision in diagnosis and treatment monitoring, modern medical imaging methods are restricted mainly to anatomical imaging, lagging behind the requirements of precision medicine. Although positron emission tomography and single photon emission computed tomography have been used clinically for studies of metabolism, their applications have been limited by the exposure risk to ionizing radiation, the subsequent limitation in repeated and longitudinal studies, and the incapability in assessing downstream metabolism. Magnetic resonance spectroscopy (MRS) or spectroscopic imaging (MRSI) are, in theory, capable of assessing molecular activities in vivo, although they are often limited by sensitivity. Here, we review some recent developments in MRS and MRSI of multiple nuclei that have potential as molecular imaging tools in the clinic. Abstract : We review some recent developments in magnetic resonance spectroscopy (MRS) and magnetic resonance spectroscopic imaging (MRSI) of multiple nuclei that have potential as molecular imaging tools in the clinic. We focus on their applications in a range of diseases and on the underlying improvements in polarization manipulation and signal encoding techniques. We propose the concept MR‐Nucleomics that investigates the diverse cellular processes on clinical scanners using MRS and MRSI based on the collective studies of different nuclei.