Cortical depth profiles of auditory and visual 7 T functional MRI responses in human superior temporal areas. Issue 2 (18th August 2022)

• Record Type: Journal Article
• Authors: Lankinen, Kaisu; Ahlfors, Seppo P.; Mamashli, Fahimeh; Blazejewska, Anna I.; Raij, Tommi; Turpin, Tori; Polimeni, Jonathan R.; Ahveninen, Jyrki
• Is Part Of: Human brain mapping. Volume 44:Issue 2(2023)
• Page Start: 362
• Page End: 372
• Publication Date: 2022-08-18
• Subjects: cortical layers -- feedforward/feedback -- high‐resolution fMRI; Brain mapping -- Periodicals; 611.81
• DOI: 10.1002/hbm.26046
• Languages: English
• ISSNs: 1065-9471

Abstract

Abstract: Invasive neurophysiological studies in nonhuman primates have shown different laminar activation profiles to auditory vs. visual stimuli in auditory cortices and adjacent polymodal areas. Means to examine the underlying feedforward vs. feedback type influences noninvasively have been limited in humans. Here, using 1‐mm isotropic resolution 3D echo‐planar imaging at 7 T, we studied the intracortical depth profiles of functional magnetic resonance imaging (fMRI) blood oxygenation level dependent (BOLD) signals to brief auditory (noise bursts) and visual (checkerboard) stimuli. BOLD percent‐signal‐changes were estimated at 11 equally spaced intracortical depths, within regions‐of‐interest encompassing auditory (Heschl's gyrus, Heschl's sulcus, planum temporale, and posterior superior temporal gyrus) and polymodal (middle and posterior superior temporal sulcus) areas. Effects of differing BOLD signal strengths for auditory and visual stimuli were controlled via normalization and statistical modeling. The BOLD depth profile shapes, modeled with quadratic regression, were significantly different for auditory vs. visual stimuli in auditory cortices, but not in polymodal areas. The different depth profiles could reflect sensory‐specific feedforward versus cross‐sensory feedback influences, previously shown in laminar recordings in nonhuman primates. The results suggest that intracortical BOLD profiles can help distinguish between feedforward and feedback type influences in the human brain. Further experimental studies are still needed to clarify how underlying signal strength influences BOLD depth profiles under different stimulus conditions. Abstract : Intracortical depth profiles of the human auditory cortex were studied with 7 T functional magnetic resonance imaging. Depth profiles to auditory and visual stimulation differed in the auditory cortex. The different depth profiles could reflect feedforward vs. feedback influences.