Bio‐functional hydrogel with antibacterial and anti‐inflammatory dual properties to combat with burn wound infection. Issue 1 (5th July 2022)

• Record Type: Journal Article
• Authors: Xiong, Yahui; Xu, Yingbin; Zhou, Fei; Hu, Yanke; Zhao, Jingling; Liu, Zhonghua; Zhai, Qiyi; Qi, Shaohai; Zhang, Zhaoqiang; Chen, Lei
• Is Part Of: Bioengineering & translational medicine. Volume 8:Issue 1(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-07-05
• Subjects: Ag‐metal–organic framework -- burn wound infection -- epigallocatechin gallate -- macrophage polarization -- methacrylate gelatin; Bioengineering -- Periodicals; Drug development -- Periodicals; Drugs -- Testing -- Periodicals; 660.6
• DOI: 10.1002/btm2.10373
• Languages: English
• ISSNs: 2380-6761

Abstract

Abstract: Burn infection delays wound healing and increases the burn patient mortality. Consequently, a new dressing with antibacterial and anti‐inflammatory dual properties is urgently required for wound healing. In this study, we propose a combination of methacrylate gelatin (GelMA) hydrogel system with silver nanoparticles embed in γ‐cyclodextrin metal–organic frameworks (Ag@MOF) and hyaluronic acid‐epigallocatechin gallate (HA‐E) for the burn wound infection treatment. Ag@MOF is used as an antibacterial agent and epigallocatechin gallate (EGCG) has exhibited biological properties of anti‐inflammation and antibacterial. The GelMA/HA‐E/Ag@MOF hydrogel enjoys suitable physical properties and sustained release of Ag + . Meanwhile, the hydrogel has excellent biocompatibility and could promote macrophage polarization from M1 to M2. In vivo wound healing evaluations further demonstrate that the GelMA/HA‐E/Ag@MOF hydrogel reduces the number of the bacterium efficiently, accelerates wound healing, promotes early angiogenesis, and regulates immune reaction. A further evaluation indicates that the noncanonical Wnt signal pathway is significantly activated in the GelMA/HA‐E/Ag@MOF hydrogel treated group. In conclusion, the GelMA/HA‐E/Ag@MOF hydrogel could serve as a promising multifunctional dressing for the burn wound healing.