EPIGENETIC MECHANISMS OF TISSUE AGING. (20th December 2022)

• Record Type: Journal Article
• Authors: Sen, Payel; Yang, Na; Occean, James; Melters, Daniel; Shi, Changyou; Wang, Lin; Sidoli, Simone; Dalal, Yamini
• Is Part Of: Innovation in aging. Volume 6(2022)Supplement 1
• Page Start: 29
• Page End: 29
• Publication Date: 2022-12-20
• Subjects: Aging -- Periodicals; Gerontology -- Periodicals; 612.67
• DOI: 10.1093/geroni/igac059.106
• Languages: English
• ISSNs: 2399-5300

Abstract

Abstract: Epigenetic alterations are one of the key hallmarks of aging. How epigenetic changes broadly affect euchromatin-heterochromatin balance, three-dimensional chromatin conformation, histone composition and global transcriptome in aging have not been addressed. Using murine liver as a model organ and an integrated multi-omics approach, we find that aged cells assume a repressed chromatin state characterized by condensed chromatin, broad heterochromatinization, global suppression of the transcriptome, and inability to self-interact over long distances. Our findings reveal that global chromatin alterations pose a barrier and promote a cellular state that is refractory to injury sensing and repair.