Dose‐response relationship between late‐life physical activity and incident dementia: A pooled analysis of 10 cohort studies of memory in an international consortium. Issue 1 (15th March 2022)

• Record Type: Journal Article
• Authors: Wu, Wanqing; Ding, Ding; Zhao, Qianhua; Xiao, Zhenxu; Luo, Jianfeng; Ganguli, Mary; Hughes, Tiffany F.; Jacobsen, Erin; Haan, Mary N.; van Dang, Kristine; Lima‐Costa, Maria Fernanda; Blay, Sergio Luis; de Castro‐Costa, Erico; Ng, Tze Pin; Gwee, Xinyi; Gao, Qi; Gureje, Oye; Ojagbemi, Akin; Bello, Toyin; Shahar, Suzana; Ludin, Arimi Fitri Mat; Rivan, Nurul Fatin Malek; Scarmeas, Nikolaos; Anastasiou, Costas A.; Yannakoulia, Mary; Brodaty, Henry; Crawford, John D.; Lipton, Richard B.; Derby, Carol A.; Katz, Mindy J.; Lipnicki, Darren M.; Sachdev, Perminder S.;
• Is Part Of: Alzheimer's & dementia. Volume 19:Issue 1(2023)
• Page Start: 107
• Page End: 122
• Publication Date: 2022-03-15
• Subjects: cohort -- dementia -- dose‐response -- physical activity -- pooled analysis -- population‐based; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1002/alz.12628
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Introduction: Though consistent evidence suggests that physical activity may delay dementia onset, the duration and amount of activity required remains unclear. Methods: We harmonized longitudinal data of 11, 988 participants from 10 cohorts in eight countries to examine the dose‐response relationship between late‐life physical activity and incident dementia among older adults. Results: Using no physical activity as a reference, dementia risk decreased with duration of physical activity up to 3.1 to 6.0 hours/week (hazard ratio [HR] 0.88, 95% confidence interval [CI] 0.67 to 1.15 for 0.1 to 3.0 hours/week; HR 0.68, 95% CI 0.52 to 0.89 for 3.1 to 6.0 hours/week), but plateaued with higher duration. For the amount of physical activity, a similar pattern of dose‐response curve was observed, with an inflection point of 9.1 to 18.0 metabolic equivalent value (MET)‐hours/week (HR 0.92, 95% CI 0.70 to 1.22 for 0.1 to 9.0 MET‐hours/week; HR 0.70, 95% CI 0.53 to 0.93 for 9.1 to 18.0 MET‐hours/week). Discussion: This cross‐national analysis suggests that performing 3.1 to 6.0 hours of physical activity and expending 9.1 to 18.0/MET‐hours of energy per week may reduce dementia risk.