P380Cardiac autonomic nervous system function in early period after radiofrequency ablation-induced destruction of paraganglionic nervous plexuses. (15th July 2014)

• Record Type: Journal Article
• Authors: Evtushenko, V; Petlin, K; Smyshlyaev, K; Saushkina, YU
• Is Part Of: Cardiovascular research. Volume 103(2014)Supplement 1
• Page Start: S69
• Page End: S70
• Publication Date: 2014-07-15
• Subjects: Cardiovascular system -- Diseases -- Periodicals; Cardiovascular system -- Periodicals; 616.1
• DOI: 10.1093/cvr/cvu091.63
• Languages: English
• ISSNs: 0008-6363

Abstract

Abstract: Purpose: The aim of the study was to evaluate the quality of radiofrequency (RF)-induced cardiac denervation by using non-invasive methods. Materials and Methods: The study included 19 patients with NYHA functional class III/IV heart failure (mean age: 60 ± 9.4 years). All patients underwent surgical treatment of valvular diseases. Patients were assigned to two groups: group 1: 11 patients with AF who underwent RF maze procedure with destruction of paraganglionic nervous plexuses; group 2: 8 patients with SR without denervation. All patients received examination of cardiac sympathetic tone by scintigraphy using 123I- metaiodobenzylguanidine (123I-MIBG). Results: Before surgery, patients with AF had significantly lower heart-to-mediastinum (H/M) ratio (1.64 ± 0.21 vs. 1.9 ± 0.27; p < 0.05) and significantly higher indicator washout rate (30.21 ± 10.43% vs. 21.94 ± 15.01%; p < 0.05) compared with group of patients with sinus rhythm. According to data of regional sympathetic activity evaluation, patients of both groups had similar defects in accumulation of 123I-MIBG before surgery (11.1 ± 5.6% vs. 8.9 ± 5.0%; p = 0.057). Patients with cardiac denervation showed a significant decrease in H/M indexes compared with the corresponding values before surgery (1.64 ± 0.21 vs. 1.42 ± 0.18; p < 0.05). Defect of accumulation significantly increased (11.1 ± 5.6% vs. 24.9 ± 7.56; p < 0.05). Patients without denervation had statistically significant decrease only in H/M index (1.9 ± 0.27 vs. 1.63 ± 0.24; p < 0.5). The study showed that washout rate of 123I-MIBG significantly changed after surgery (36 ± 13.38% vs. 25.14 ± 9.96%; p < 0.05). Patients with AF had significantly lower H/M index compared with group of patients with sinus rhythm (1.42 ± 0.18 vs. 1.63 ± 0.24; p < 0.05). Evaluation of regional sympathetic activity showed that 123I-MIBG accumulation defect was significantly larger in patients with cardiac denervation compared with group of patients without it (24.9% ± 7.56% vs. 13.7 ± 5.81%; p < 0.05). Conclusions: Data of the study showed that patients who underwent destruction of paraganglionic nervous plexuses had statistically significant increase of 123I-MIBG washout rate, decrease of H/M index on early and delayed scintigrams, and increase of 123I-MIBG accumulation defect suggesting that this method may be used for the quality evaluation of cardiac sympathetic denervation in the postoperative period.