Clinical value of normal saline injection for expansion of the anterior perirectal space during prostate cryoablation. Issue 1 (January 2023)

• Record Type: Journal Article
• Authors: Wang, Ning; Zhao, Di-wei; Chen, Dong; Wu, Zhi-ming; Wang, Yan-jun; Yang, Zhen-yu; Zhao, Jun-liang; Zhou, Fang-jian; Li, Yong-hong
• Is Part Of: European journal of surgical oncology. Volume 49:Issue 1(2023)
• Page Start: 252
• Page End: 256
• Publication Date: 2023-01
• Subjects: Normal saline injection -- Cryoablation -- Prostate cancer -- Urethrorectal fistula; Oncology -- Periodicals; Cancer -- Surgery -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- surgery -- Periodicals; Cancer -- Chirurgie -- Périodiques; Cancérologie -- Périodiques; Oncologie; Chirurgie (geneeskunde); Electronic journals; Electronic journals -- Sciences; Electronic journals -- Medicine; Electronic journals; 616.994059005
• DOI: 10.1016/j.ejso.2022.06.032
• Languages: English
• ISSNs: 0748-7983

Abstract

Abstract: Background: The objective of this study is to describe the technique and evaluate the clinical value of normal saline (NS) injection for expanding the anterior perirectal space during prostate cryoablation for prostate cancer (PCa) patients. Methods: PCa patients who received cryoablation between August 2014 and December 2019 were enrolled, and the technique of NS injection was adopted. The complications were evaluated. The prostate-specific antigen (PSA) nadir and biochemical progression-free survival (bPFS) were measured in localized PCa patients who received cryoablation as the primary treatment. Results: A total of 159 PCa patients were included. Among 147 patients with the data of anterior perirectal space, the median (interquartile range [IQR]) distance of estimated iceball edge beyond the prostatic capsule was 8.3 (7.0–10.0) mm. No cases of urethrorectal fistula were reported; 29 patients developed urinary retention and 25 patients presented scrotal edema. All complications below Clavien-Dindo grade IIIb disappeared within 7 weeks after surgery. Urinary incontinence was reported in 6 patients. Among localized PCa patients, the median (IQR) follow-up time was 56.5 (36.0–73.5) months. The estimated 5-year bPFS was 82.3% overall, 82.8% for low-to intermediate-risk PCa patients, and 82.1% for high-risk PCa patients. For 52 patients received cryoablation alone, the median (IQR) PSA nadir was 0.147 (0.027–0.381) ng/mL. Conclusions: The technique of NS injection for expanding the anterior perirectal space during cryoablation surgery could avoid urethrorectal fistula and might benefit localized PCa patients with lower PSA nadir and longer bPFS.