Synergy and regulation of antiphage systems: toward the existence of a bacterial immune system?. (February 2023)

• Record Type: Journal Article
• Authors: Tesson, Florian; Bernheim, Aude
• Is Part Of: Current opinion in microbiology. Volume 71(2023)
• Publication Date: 2023-02
• Subjects: Microbiology -- Periodicals; 579.05
• DOI: 10.1016/j.mib.2022.102238
• Languages: English
• ISSNs: 1369-5274

Abstract

Abstract : Bacteria encode a vast repertoire of diverse antiphage defense systems. Recent studies revealed that different defense systems are often encoded within the same genome, raising the question of their possible interactions in a cell. Here, we review the known synergies and coregulations of antiphage systems. The emerging complexities suggest a potential existence of an additional level of organization of antiviral defense in prokaryotes. We argue that this organization could be compared with immune systems of animals and plants. We discuss this concept and explore what it could mean in bacteria. Highlights: Different antiphage systems are encoded in one bacterial genome. Bacterial antiphage systems can function in synergy through different strategies. Antiphage systems can be co-regulated.