Comparing adaptive coding of reward in bipolar I disorder and schizophrenia. Issue 2 (16th September 2022)

• Record Type: Journal Article
• Authors: Kaliuzhna, Mariia; Kirschner, Matthias; Tobler, Philippe N.; Kaiser, Stefan
• Is Part Of: Human brain mapping. Volume 44:Issue 2(2023)
• Page Start: 523
• Page End: 534
• Publication Date: 2022-09-16
• Subjects: adaptive coding -- bipolar disorder -- fMRI -- monetary incentive delay task -- reward processing -- schizophrenia; Brain mapping -- Periodicals; 611.81
• DOI: 10.1002/hbm.26078
• Languages: English
• ISSNs: 1065-9471

Abstract

Abstract: Deficits in neural processing of reward have been described in both bipolar disorder (BD) and schizophrenia (SZ), but it remains unclear to what extent these deficits are caused by similar mechanisms. Efficient reward processing relies on adaptive coding which allows representing large input spans by limited neuronal encoding ranges. Deficits in adaptive coding of reward have previously been observed across the SZ spectrum and correlated with total symptom severity. In the present work, we sought to establish whether adaptive coding is similarly affected in patients with BD. Twenty‐five patients with BD, 27 patients with SZ and 25 healthy controls performed a variant of the Monetary Incentive Delay task during functional magnetic resonance imaging in two reward range conditions. Adaptive coding was impaired in the posterior part of the right caudate in BD and SZ (trend level). In contrast, BD did not show impaired adaptive coding in the anterior caudate and right precentral gyrus/insula, where SZ showed deficits compared to healthy controls. BD patients show adaptive coding deficits that are similar to those observed in SZ in the right posterior caudate. Adaptive coding in BD appeared more preserved as compared to SZ participants especially in the more anterior part of the right caudate and to a lesser extent also in the right precentral gyrus. Thus, dysfunctional adaptive coding could constitute a fundamental deficit in severe mental illnesses that extends beyond the SZ spectrum. Abstract : Patients with schizophrenia show reduced adaptation to reward context, a feature that could play a role in the symptoms of apathy. We show that patients with Bipolar disorder also show a deficit in adaptive coding of reward.