Enhanced Fiber Tractography Using Edema Correction: Application and Evaluation in High-Grade Gliomas. Issue 2 (29th April 2021)

• Record Type: Journal Article
• Authors: Henderson Jr, Fraser; Parker, Drew; Vijayakumari, Anupa A; Elliott, Mark; Lucas, Timothy; McGarvey, Michael L; Karpf, Lauren; Desiderio, Lisa; Harsch, Jessica; Levy, Scott; Maloney-Wilensky, Eileen; Wolf, Ronald L; Hodges, Wesley B; Brem, Steven; Verma, Ragini
• Is Part Of: Neurosurgery. Volume 89:Issue 2(2021)
• Page Start: 246
• Page End: 256
• Publication Date: 2021-04-29
• Subjects: Diffusion tensor imaging, Tractography, Glioblastoma -- Free water correction, Edema invariance; Nervous system -- Surgery -- Periodicals; 617.48005
• DOI: 10.1093/neuros/nyab129
• Languages: English
• ISSNs: 0148-396X

Abstract

Abstract: BACKGROUND: A limitation of diffusion tensor imaging (DTI)-based tractography is peritumoral edema that confounds traditional diffusion-based magnetic resonance metrics. OBJECTIVE: To augment fiber-tracking through peritumoral regions by performing novel edema correction on clinically feasible DTI acquisitions and assess the accuracy of the fiber-tracks using intraoperative stimulation mapping (ISM), task-based functional magnetic resonance imaging (fMRI) activation maps, and postoperative follow-up as reference standards. METHODS: Edema correction, using our bi-compartment free water modeling algorithm (FERNET), was performed on clinically acquired DTI data from a cohort of 10 patients presenting with suspected high-grade glioma and peritumoral edema in proximity to and/or infiltrating language or motor pathways. Deterministic fiber-tracking was then performed on the corrected and uncorrected DTI to identify tracts pertaining to the eloquent region involved (language or motor). Tracking results were compared visually and quantitatively using mean fiber count, voxel count, and mean fiber length. The tracts through the edematous region were verified based on overlay with the corresponding motor or language task-based fMRI activation maps and intraoperative ISM points, as well as at time points after surgery when peritumoral edema had subsided. RESULTS: Volume and number of fibers increased with application of edema correction; concordantly, mean fractional anisotropy decreased. Overlay with functional activation maps and ISM-verified eloquence of the increased fibers. Comparison with postsurgical follow-up scans with lower edema further confirmed the accuracy of the tracts. CONCLUSION: This method of edema correction can be applied to standard clinical DTI to improve visualization of motor and language tracts in patients with glioma-associated peritumoral edema.