A small molecule improves diabetes in mice expressing human islet amyloid polypeptide. Issue 1 (31st December 2023)

• Record Type: Journal Article
• Authors: Bhagat, Vriti; Verchere, C. Bruce
• Is Part Of: Islets. Volume 15:Issue 1(2023)
• Page Start: 12
• Page End: 15
• Publication Date: 2023-12-31
• Subjects: Islets -- beta cells -- amyloid -- islet amyloid polypeptide -- amylin -- small molecule -- autophagy; Islands of Langerhans -- Periodicals; Pancreas -- Periodicals; 616.46
• DOI: 10.1080/19382014.2022.2163829
• Languages: English
• ISSNs: 1938-2022

Abstract

ABSTRACT: In recent years, the number of studies on islet and beta cell autophagy have substantially increased due to growing interest in the role of autophagy in maintaining cellular homeostasis in diabetes. In type 2 diabetes, human islet amyloid polypeptide (hIAPP) aggregates to form higher structure oligomers and fibrils that are toxic to beta cells and induce islet inflammation. The primary mechanism of oligomer and fibril clearance in beta cells is through the autophagic pathway, a process that is impaired in type 2 diabetes. Thus, toxic oligomeric and fibrillar forms of hIAPP accumulate in type 2 diabetic islets. Recently, Kim et al . characterized the ability of a small molecule autophagy enhancer, MSL-7, to clear hIAPP oligomers in mice expressing hIAPP. Herein, we outline the primary findings of the study, limitations, and future directions to further investigate the therapeutic potential of autophagy enhancers to treat diabetes. Graphical Abstract: uf0001