Bile acids and their receptors in regulation of gut health and diseases. (January 2023)

• Record Type: Journal Article
• Authors: Lin, Sen; Wang, Sutian; Wang, Peng; Tang, Cuiming; Wang, Zhenjiang; Chen, Lian; Luo, Guoqing; Chen, Hong; Liu, Yuntao; Feng, Bin; Wu, De; Burrin, Douglas G.; Fang, Zhengfeng
• Is Part Of: Progress in lipid research. Volume 89(2023)
• Publication Date: 2023-01
• Subjects: Bile acids -- FXR -- GPBAR1 -- Inflammatory bowel diseases -- Colorectal cancers; AC adenylate cyclase -- AKT protein kinase B -- ASBT apical sodium-dependent BA transporter -- BAD bile acid diarrhea -- BARs bile acids activated receptors -- BAs bile acids -- BAT brown adipose tissues -- BSEP bile salt export pulp -- BSH bile salt hydrolase -- CA cholic acid -- cAMP Cyclic adenosine monophosphate -- CAR constitutive androstane receptor -- CDCA chenodeoxycholic acid -- CRC colorectal cancer -- CREBP cAMP response element binding protein -- CYP7A1 cholesterol 7α-hydroxylase -- CYP7B1 oxysterol 7α-hydrolase -- CYP8B1 sterol 12α-hydroxylase -- CYP27A1 sterol 27-hydroxylase -- DCA deoxycholic acid -- DIO2 type 2 iodothyronine deiodinase -- EGFR epidermal growth factor receptor -- ERK extracellular signal-regulated kinases -- FGF fibroblast growth factor -- FGFR4 fibroblast growth factor receptor 4 -- FXR Farnesoid X receptor -- GCA glycolcholic acid -- GDCA glycodeoxycholic acid -- GLP glucagon-like peptide -- GPBAR1 G protein-coupled bile acid receptor 1 -- HCA hyocholic acid -- IBABP ileal bile acid binding protein -- IBDs inflammatory bowel diseases -- ICP intrahepatic cholestasis of pregnancy -- IFN Interferon -- IL interleukin -- IP3 inositol trisphosphate -- IR insulin receptor -- JNK c-Jun N-terminal kinase -- LCA lithocholic acid -- LPS lipopolysaccharide -- LRH-1 liver related homolog-1 -- MCA muricholic acid -- MRP3 ABC transporter -- NF-κB nuclear factor κB -- NLRP3 NLR family pyrin domain containing 3 -- NTCP sodium taurocholate co-transporting polypeptide -- OATP transporting polypeptide -- OCA obeticholic acid -- OST organic solute transporter -- PBA primary bile acids -- PKA protein kinase A -- PXR pregnane X receptor -- S1PR2 sphingosine 1-phosphate receptor 2 -- SBA secondary bile acids -- SHP small heterodimer partner -- T3 triiodothyronine -- T4 thyroxine -- TCA taurocholate -- TDCA taurodeoxycholic acid -- TGF transforming growth factor -- TNF tumor necrosis factor -- TUDCA tauroursodeoxycholic acid -- UC ulcerative colitis -- UDCA ursodeoxycholic acid -- VDR vitamin D receptor -- Wnt wingless and int-1; Lipids -- Periodicals; Lipids -- Periodicals; Lipides -- Périodiques; Lipiden; 572.57
• DOI: 10.1016/j.plipres.2022.101210
• Languages: English
• ISSNs: 0163-7827

Abstract

Abstract: It is well established that bile acids play important roles in lipid metabolism. In recent decades, bile acids have also been shown to function as signaling molecules via interacting with various receptors. Bile acids circulate continuously through the enterohepatic circulation and go through microbial transformation by gut microbes, and thus bile acids metabolism has profound effects on the liver and intestinal tissues as well as the gut microbiota. Farnesoid X receptor and G protein-coupled bile acid receptor 1 are two pivotal bile acid receptors that highly expressed in the intestinal tissues, and they have emerged as pivotal regulators in bile acids metabolism, innate immunity and inflammatory responses. There is considerable interest in manipulating the metabolism of bile acids and the expression of bile acid receptors as this may be a promising strategy to regulate intestinal health and disease. This review aims to summarize the roles of bile acids and their receptors in regulation of gut health and diseases.