Geraniol prevents Helicobacterium pylori-induced human gastric cancer signalling by enhancing peroxiredoxin-1 expression in GES-1 cells. (January 2023)

• Record Type: Journal Article
• Authors: Zhuang, Kun; Tang, Hailing; Guo, Hanqing; Yuan, Shanshan
• Is Part Of: Microbial pathogenesis. Volume 174(2023)
• Publication Date: 2023-01
• Subjects: Geraniol -- Gastric cancer -- H. pylori -- GES-1 cell line -- Oxidative DNA damage; Pathogenic microorganisms -- Periodicals; Pathology, Molecular -- Periodicals; Communicable Diseases -- microbiology -- Periodicals; Communicable Diseases -- parasitology -- Periodicals; Micro-organismes pathogènes -- Périodiques; Pathologie moléculaire -- Périodiques; Electronic journals; 616.9041
• DOI: 10.1016/j.micpath.2022.105937
• Languages: English
• ISSNs: 0882-4010

Abstract

Abstract: Helicobacter pylori (H. pylori), a gram-negative bacterial microbiological carcinogen, has been identified as the leading jeopardy feature for developing human gastric cancer (GC). As a result, inhibiting H. pylori growth has been identified as an effective and critical technique for preventing GC development. In this study, geraniol inhibits H. pylori -induced gastric carcinogen signalling in human gastric epithelial cells (GES-1). Geraniol prevents cytotoxicity, ROS and apoptosis in H. pylori -induced GES-1 cells. Furthermore, geraniol protects against H. -induced antioxidant depletion caused by malondialdehyde, damage of reactive DNA and nuclear fragmentation. Geraniol significantly reduced the expression of phosphorylated mitogen activated protein kinases (MAPKs) proteins such as p38 MAPK, extracellular signal-regulated kinase-1 (ERK1), c-Jun N-terminal kinase (c-JNK), tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and cyclooxygenase-2 (COX-2) in GES-1 infected with H. pylori . Furthermore, geraniol increased the antioxidant protein peroxiredoxin-1 (Prdx-1) in H. pylori -infected cells. Geraniol thus protects H. pylori -concomitant infection, and its resistance may be a possible method in preventing gastric cancer caused by H. pylori . Highlights: H. pylori is bacterial pathogen for inducing GC. H. pylori infection produces MAPKs, PI3K/AKT phosphorylation. Geraniol a natural remedy prevents H. pylori associated GC induction. Geraniol prevents GC induction via enhancing Prdx1 expression.