Autophagic secretion of mitochondria (ASM): an alternative way for getting rid of damaged mitochondria. Issue 2 (1st February 2023)

• Record Type: Journal Article
• Authors: Tan, Hayden Weng Siong; Lu, Guang; Shen, Han-Ming
• Is Part Of: Autophagy. Volume 19:Issue 2(2023)
• Page Start: 739
• Page End: 741
• Publication Date: 2023-02-01
• Subjects: Extracellular vesicles -- inflammation -- mATG8 conjugation system -- mitochondrial quality control -- mitophagy -- PINK1-PRKN -- secretory autophagy; Autophagic vacuoles -- Periodicals; Apoptosis -- Periodicals; Cell death -- Periodicals; Lysosomes -- Periodicals; Degeneration (Pathology) -- Periodicals; Autophagy -- Periodicals; Cell Death -- Periodicals; Lysosomes -- Periodicals; Periodicals; 571.936
• DOI: 10.1080/15548627.2022.2107310
• Languages: English
• ISSNs: 1554-8627

Abstract

ABSTRACT: PINK1-PRKN/Parkin-mediated mitophagy represents an important mitochondrial quality control (MQC) pathway that clears damaged/dysfunctional mitochondria. Although the conjugation of mammalian Atg8-family proteins (mATG8s) to phosphatidylethanolamine (PE) is a defining step in autophagy, its role in mitophagy remains unclear. In our recent study, we found that the mATG8 conjugation system is not required for PINK1-PRKN-mediated mitochondria clearance. Instead, mATG8 conjugation system-independent mitochondria clearance relies on secretory autophagy, a process we term as the autophagic secretion of mitochondria (ASM). As ASM results in the spurious activation of the CGAS-STING1 pathway, we propose that defects in mATG8 lipidation may promote inflammation through ASM.