Host cell responses against the pseudomonal biofilm: A continued tale of host-pathogen interactions. (January 2023)

• Record Type: Journal Article
• Authors: Sankar, Sathish; Ganesh, Pitchaipillai Sankar; Subramaniam, Suganya; Shankar, Esaki M; Yuwanati, Monal; Govindasamy, Rajakumar; Thiruvengadam, Muthu
• Is Part Of: Microbial pathogenesis. Volume 174(2023)
• Publication Date: 2023-01
• Subjects: Biofilm -- P. aeruginosa -- Quorum sensing -- Therapeutics -- Virulence; Pathogenic microorganisms -- Periodicals; Pathology, Molecular -- Periodicals; Communicable Diseases -- microbiology -- Periodicals; Communicable Diseases -- parasitology -- Periodicals; Micro-organismes pathogènes -- Périodiques; Pathologie moléculaire -- Périodiques; Electronic journals; 616.9041
• DOI: 10.1016/j.micpath.2022.105940
• Languages: English
• ISSNs: 0882-4010

Abstract

Abstract: In biofilm formation, pathogens within the bacterial community coordinate a cell-cell communication system called quorum sensing (QS). This is achieved through various signalling pathways that regulate bacterial virulence and host immune response. Here, we reviewed the host responses, key clinical implications, and novel therapeutic approaches against the biofilms of P. aeruginosa . Given the high degree of intrinsic antibiotic resistance and biofilm formation by the pathogen, the ensuing treatment complications could result in high morbidity and mortality rates worldwide. Notwithstanding the availability of intervention strategies, there remains a paucity of effective therapeutic options to control biofilmogenesis. This review discusses the basic understanding of QS-associated virulence factors and several key therapeutic interventions to foil the biofilm menace of P. aeruginosa . Highlights: No effective therapeutic options to control Pseudomanal biofilm. Host responses also play key role in QS-regulatory mechanism. There is need for novel therapeutic approaches against biofilms of P. aeruginosa . Deep understanding of complex QS mechanism opens new research opportunities.