A concise review on marine bromopyrrole alkaloids as anticancer agents. (15th January 2023)

• Record Type: Journal Article
• Authors: Mahamed, Safia; Motal, Raeesa; Govender, Titus; Dlamini, Nompilo; Khuboni, Kwanele; Hadeb, Zamahlubi; Shaik, Baji Baba; Moodley, Kimeshni; Balaso Mohite, Sachin; Karpoormath, Rajshekhar
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 80(2023)
• Publication Date: 2023-01-15
• Subjects: Bromopyrrole alkaloids -- Marine sponges -- Natural products -- Anticancer activity; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2022.129102
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Natural products have been the most important sources of chemically diverse raw materials that have inspired pharmaceutical discoveries over the past few decades. Many pharmaceutical companies are utilizing plant extracts to develop relatively crude therapeutic formulations. The interesting chemicals identified as natural products are derived from the phenomenon of biodiversity, where the interactions between the organisms and their environment formulate the diverse and complex chemical entities within them that enhance their survival and competitiveness. Marine sponges are rich sources of natural products and have provided an infinite supply of bioactive metabolites. Bromopyrrole alkaloids are a good example of marine metabolites, have a broad range of biological activity, and represent a fascinating example of chemical diversity of secondary metabolites elaborated by marine invertebrates. The isolation and synthesis of this structural class have been investigated, resulting in a series of bromopyrrole alkaloids with potential lead hits. This review presents the detailed isolation and anticancer activity of marine bromopyrrole alkaloids, and will be of interest to the wider research community both in academic and industrial settings.