Carbohydrate polymer-based nanocomposites for breast cancer treatment. (15th March 2023)

• Record Type: Journal Article
• Authors: Moghaddam, Farnaz Dabbagh; Heidari, Golnaz; Zare, Ehsan Nazarzadeh; Djatoubai, Essossimna; Paiva-Santos, Ana Cláudia; Bertani, Francesca Romana; Wu, Aimin
• Is Part Of: Carbohydrate polymers. Volume 304(2023)
• Publication Date: 2023-03-15
• Subjects: Carbohydrate -- Nanocomposite -- Nanocarrier -- Breast cancer -- Treatment; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2022.120510
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: Breast cancer is known as the most common invasive malignancy in women with the highest mortality rate worldwide. This concerning disease may be presented in situ (relatively easier treatment) or be invasive, especially invasive ductal carcinoma which is highly worrisome nowadays. Among several strategies used in breast cancer treatment, nanotechnology-based targeted therapy is currently being investigated, as it depicts advanced technological features able of preventing drugs' side effects on normal cells while effectively acting on tumor cells. In this context, carbohydrate polymer-based nanocomposites have gained particular interest among the biomedical community for breast cancer therapy applications due to their advantage features, including abundance in nature, biocompatibility, straightforward fabrication methods, and good physicochemical properties. In this review, the physicochemical properties and biological activities of carbohydrate polymers and their derivate nanocomposites were discussed. Then, various methods for the fabrication of carbohydrate polymer-based nanocomposites as well as their application in breast cancer therapy and future perspectives were discussed. Graphical abstract: Unlabelled Image