Highly oxygenated diterpenoids in Clerodendranthus spicatus and their bioactivity, A review. (February 2023)

• Record Type: Journal Article
• Authors: Zhang, Yaqi; Fu, Yang; Ruan, Jingya; Gao, Qian; Yang, Dingshan; Wang, Dan; Zhang, Yi; Wang, Tao
• Is Part Of: Biochemical systematics and ecology. Volume 106(2023)
• Publication Date: 2023-02
• Subjects: Clerodendranthus spicatus (Thunb.) C. Y. Wu -- Highly diterpenoids -- Bioactivity -- Structure-activity relationships; Chemotaxonomy -- Periodicals; Biochemical variation -- Periodicals; Ecology -- Periodicals; Biochemistry -- Periodicals; Ecology -- Periodicals; Chimiotaxinomie -- Périodiques; Variation biochimique -- Périodiques; Écologie -- Périodiques; 578.012
• DOI: 10.1016/j.bse.2022.104580
• Languages: English
• ISSNs: 0305-1978

Abstract

Abstract: Clerodendranthus spicatus (Thunb.) C. Y. Wu possesses a definite curative effect in treating acute and chronic kidney diseases, gout, and urinary system diseases, and has been used as a national medicine for thousands of years. Meanwhile, as its toxic side effects are minimal, C. spicatus has been widely used as a healthy tea-"kidney tea" to improve kidney function. As the specific and main secondary metabolites of C. spicatus, the highly oxygenated diterpenoids exhibit various pharmacological effects such as anti-inflammation, anti-tumor, inhibition of renal fibrosis, treatment of gout, and anti-diabetes. The detailed phytochemistry, plant origin, bioactivity, and structure-activity relationships of them were surveyed here firstly to lay a foundation for the further development of the plant. Highlights: Highly oxygenated diterpenoids (HODs) are abundant in C. spicatus. HODs are the main specific secondary metabolites of C. spicatus. The phytochemistry, plant origin, bioactivity of C. spicatu HODs were summarized. The foundation for further development of the plant would be laid.