Review: Status and prospects of association mapping in grapevine. (February 2023)

• Record Type: Journal Article
• Authors: Tello, Javier; Ibáñez, Javier
• Is Part Of: Plant science. Volume 327(2023)
• Publication Date: 2023-02
• Subjects: ABA Abscisic acid -- AM Association mapping -- CGAS Candidate-gene association study -- CRISPR Clustered regularly interspaced short palindromic repeats -- FDR False discovery rate -- flb Fleshless berry -- GWAS Genome-wide association study -- INDEL Insertion/Deletion -- LD Linkage disequilibrium -- MAS Marker-assisted selection -- MLM Mixed linear model -- MLMM Multi-locus mixed model -- MWAS Metabolome-wide association study -- NB-LRR Nucleotide binding-leucine-rich repeat -- Q-Q Quantile–quantile -- QTL Quantitative trait locus -- QTN Quantitative trait nucleotide -- RRM Reiterated reproductive meristem -- SdI Seed development inhibitor -- SNP Single nucleotide polymorphism -- SSR Simple sequence repeat -- SV Structural variation -- TWAS Transcriptome-wide association study -- VIVC Vitis International Variety Catalogue; Breeding -- Genetic diversity -- GWAS -- QTL -- Vitis vinifera L; Botany -- Periodicals; Botanique -- Périodiques; 580
• DOI: 10.1016/j.plantsci.2022.111539
• Languages: English
• ISSNs: 0168-9452

Abstract

Abstract: Thanks to current advances in sequencing technologies, novel bioinformatics tools, and efficient modeling solutions, association mapping has become a widely accepted approach to unravel the link between genotype and phenotype diversity in numerous crops. In grapevine, this strategy has been used in the last decades to understand the genetic basis of traits of agronomic interest (fruit quality, crop yield, biotic and abiotic resistance), of special relevance nowadays to improve crop resilience to cope with future climate scenarios. Genome-wide association studies have identified many putative causative loci for different traits, some of them overlapping well-known causal genes identified by conventional quantitative trait loci studies in biparental progenies, and/or validated by functional approaches. In addition, candidate-gene association studies have been useful to pinpoint the causal mutation underlying phenotypic variation for several traits of high interest in breeding programs (like berry color, seedlessness, and muscat flavor), information that has been used to develop highly informative and useful markers already in use in marker-assisted selection processes. Thus, association mapping has proved to represent a valuable step towards high quality and sustainable grape production. This review summarizes current applications of association mapping in grapevine research and discusses future prospects in view of current viticulture challenges. Highlights: This review covers recent advances in the use of association mapping (AM) in grapevine research. GWAS have eased the genetic dissection of relevant traits. CGAS have pinpointed the causal mutation underlying major determining QTLs. successful applications of AM results for grapevine breeding activities are shown. AM opportunities and limitations are discussed, considering current viticulture challenges.