New boro amino amide organocatalysts for asymmetric cross aldol reaction of ketones with carbonyl compounds. Issue 2 (4th January 2023)

• Record Type: Journal Article
• Authors: Begum, Zubeda; Seki, Chigusa; Okuyama, Yuko; Kwon, Eunsang; Uwai, Koji; Tokiwa, Michio; Tokiwa, Suguru; Takeshita, Mitsuhiro; Nakano, Hiroto
• Is Part Of: RSC advances. Volume 13:Issue 2(2023)
• Page Start: 888
• Page End: 894
• Publication Date: 2023-01-04
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d2ra06272k
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Distinct types of new boron fused primary amino amide organocatalysts were designed and synthesized from commercially available amino acids. Abstract : Distinct types of new boron fused primary amino amide organocatalysts were designed and synthesized from commercially available amino acids. Their catalytic activities were investigated in asymmetric crossed aldol reaction of ketones with aromatic aldehydes to afford the corresponding chiral anti -aldol adducts with good chemical yields, moderate diastereoselectivity and good to excellent enantioselectivities (up to 94% yields, up to 90 : 10 dr, up to 94% ee).