Hazard characterization of bisphenol A (BPA) based on rodent models – Multilevel meta-analysis and dose-response analysis for reproductive toxicity. (February 2023)

• Record Type: Journal Article
• Authors: Wang, Xin; Nag, Rajat; Brunton, Nigel P.; Bakar Siddique, Md Abu; Harrison, Sabine M.; Monahan, Frank J.; Cummins, Enda
• Is Part Of: Food and chemical toxicology. Volume 172(2023)
• Publication Date: 2023-02
• Subjects: Dose-response -- Reproductive organ weight -- Sperm concentration -- Sperm motility -- Risk assessment; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2022.113574
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: Bisphenol A (BPA) is a widely used synthetic industrial compound frequently detected in food. Dietary exposure to BPA has been recognised as a potential health concern. However, there are uncertainties regarding BPA toxicity. The primary objective of this study was to summarise and analyse multiple toxicity endpoints of adverse reproductive effects caused by BPA exposure in rodent models. Therefore, a multilevel meta-analysis and subsequent dose-response analysis were conducted. Relevant articles published in English between 2012 and 2021 were collected from online databases, viz . Scopus, EmBase, Web of Science, and PubMed. In total, 41 studies were included for statistical analysis. All statistical analyses were performed using open-source RStudio packages. Summary effects indicated the statistical significance of BPA exposure on decreased sperm concentration (Hedges' g: -1.35) and motility (Hedges' g: -1.12) on average, while no significant effects were observed on the absolute and relative weight of male and female reproductive organs. The lowest mean toxicological reference dose values of 0.0011 mg (kg bw) −1 day −1 was proposed for BPA exposure on sperm concentration from the dose-response model. In conclusion, potential health risks from BPA exposure were shown with regards to reproductive toxicity, especially that sperm concentration and sperm motility require further attention. Graphical abstract: Image 1 Highlights: On average, BPA significantly decreased sperm concentration and motility. The mean toxicological reference value for sperm concentration was 0.0011 mg (kg bw) −1 day −1 . There are potential health risks regarding reproductive toxicity. Multilevel meta-analysis performed better than a conventional two-level model.