Diethylstilbestrol exposure during pregnancy with primary clear cell carcinoma of the cervix in an 8-year-old granddaughter: a multigenerational effect of endocrine disruptors?. Issue 1 (4th November 2020)

• Record Type: Journal Article
• Authors: Gaspari, Laura; Paris, Françoise; Cassel-Knipping, Nathalie; Villeret, Julia; Verschuur, Arnauld; Soyer-Gobillard, Marie-Odile; Carcopino-Tusoli, Xavier; Hamamah, Samir; Kalfa, Nicolas; Sultan, Charles
• Is Part Of: Human reproduction. Volume 36:Issue 1(2021)
• Page Start: 82
• Page End: 86
• Publication Date: 2020-11-04
• Subjects: clear cell adenocarcinoma -- diethylstilbestrol -- multigenerational transmission -- transgenerational transmission -- prenatal exposure -- endocrine disrupting chemicals -- granddaughters -- fetal basis of adult disease -- in-utero exposure -- epigenetic effects; Human reproduction -- Periodicals; 618
• DOI: 10.1093/humrep/deaa267
• Languages: English
• ISSNs: 0268-1161

Abstract

ABSTRACT: To date, vaginal/cervical clear cell adenocarcinoma (CCAC) has not been reported in the granddaughters of women treated with diethylstilbestrol (DES) during pregnancy. We present an 8-year-old girl with a history of severe vaginal bleeding who was diagnosed with cervical CCAC. She underwent fertility-sparing surgery and radiotherapy. No sign of recurrence was detected throughout a 10-year follow-up. Her grandmother had received DES therapy during pregnancy with the patient's mother. Although no direct causal link is demonstrated, this case raises for the first time, the hypothesis of multigenerational effects of DES in girls and strongly suggests the need to follow the granddaughters of DES-treated women.