Secretors of HBGA and Susceptibility to Norovirus and Rotavirus Diarrhea. Issue 9 (September 2021)

• Record Type: Journal Article
• Authors: Faden, Howard; Schaefer, Beverly A.
• Is Part Of: Pediatric infectious disease journal. Volume 40:Issue 9(2021)
• Publication Date: 2021-09
• Subjects: histo-blood group antigens -- secretor of HBGA -- diarrhea -- rotavirus -- norovirus; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000003218
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : Histo-blood group antigen contains oligosaccharides that serve as receptors for norovirus (NoV) and rotavirus (RV). The receptors are only present on the surface of intestinal mucosal epithelial cells of secretors; therefore, secretors are susceptible to NoV and RV diarrhea and nonsecretors are resistant. The prevalence of secretors in different countries varies between 50% and 90%. Secretor rates evolved in response to environmental pressures such as infectious diseases.