Oculomotor deficits in attention deficit hyperactivity disorder (ADHD): A systematic review and comprehensive meta-analysis. (December 2021)

• Record Type: Journal Article
• Authors: Maron, Dalia N.; Bowe, Steven J.; Spencer-Smith, Megan; Mellahn, Olivia J.; Perrykkad, Kelsey; Bellgrove, Mark A.; Johnson, Beth P.
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 131(2021)
• Page Start: 1198
• Page End: 1213
• Publication Date: 2021-12
• Subjects: ADHD -- Oculomotor -- Inhibition -- Working memory -- Motor coordination; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2021.10.012
• Languages: English
• ISSNs: 0149-7634

Abstract

Highlights: We evaluated saccade, pursuit and fixation ocular motor profiles in ADHD. Key difficulties relating to saccade inhibition were identified for ADHD. Other difficulties related to memorizing visual target locations and initiating antisaccades. These findings highlight potential ocular motor biomarkers for ADHD. Abstract: Atypical motor coordination and cognitive processes, such as response inhibition and working memory, have been extensively researched in individuals with attention deficit hyperactivity disorder (ADHD). Oculomotor neural circuits overlap extensively with regions involved in motor planning and cognition, therefore studies of oculomotor function may offer unique insights into motor and cognitive control in ADHD. We performed a series of pairwise meta-analyses based on data from 26 oculomotor studies in ADHD to examine whether there were differences in performance on visually-guided saccade, gap, antisaccade, memory-guided, pursuit eye movements and fixation tasks. These analyses revealed oculomotor disturbances in ADHD, particularly for difficulties relating to saccade inhibition, memorizing visual target locations and initiating antisaccades. There was no evidence for pursuit eye movement disturbances or saccade dysmetria. Investigating oculomotor abnormalities in ADHD may provide insight into top-down cognitive control processes and motor control, and may serve as a promising biomarker in ADHD research and clinical practice.