Factors modulating the incubation of drug and non-drug craving and their clinical implications. (December 2021)

• Record Type: Journal Article
• Authors: Venniro, Marco; Reverte, Ingrid; Ramsey, Leslie A.; Papastrat, Kimberly M.; D'Ottavio, Ginevra; Milella, Michele Stanislaw; Li, Xuan; Grimm, Jeffrey W.; Caprioli, Daniele
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 131(2021)
• Page Start: 847
• Page End: 864
• Publication Date: 2021-12
• Subjects: SUD substance use disorder -- DSM-5 Diagnostic and Statistical Manual of Mental Disorders 5 -- GWAS genome-wide associations -- EE environmental enrichment -- REM rapid eye movement -- NREM non-rapid eye movement -- SR sleep restriction -- mPFC medial prefrontal cortex -- NAc nucleus accumbens -- BDNF brain-derived neurotrophic factor -- AMPARs AMPA receptors -- CP-AMPARs Ca2+-permeable AMPA receptors -- CI-AMPARs Ca2+-impermeable AMPAR receptors -- CeA central amygdala -- BLA basolateral amygdala -- ERK extracellular signal-regulated kinase -- LTD long-term depression -- CRFr1 CRF receptor 1 -- BNST bed nucleus of the stria terminalis -- DMS dorsomedial striatum -- AIV anterior ventral insular cortex -- OFC orbitofrontal cortex -- Pir piriform cortex -- Drd1 dopamine receptor D1 -- Drd2 dopamine receptor D2 -- PKCδ protein kinase-Cδ -- CeL central lateral amygdala -- CeM central medial amygdala -- LiCl lithium chloride -- TH tyrosine hydroxylase -- DAT dopamine transporter -- VTA ventral tegmental area -- DLS dorsolateral striatum -- IR immunoreactivity -- pERK phosphorylated extracellular signal-regulated kinase -- AMY amygdala -- NMUR2 neuromedin U receptor 2 -- PVN paraventricular nucleus of hypothalamus; Self-administration -- Relapse -- Craving -- Contingency management -- Social community approach -- Abstinence -- Incubation -- Substance use disorders; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2021.09.050
• Languages: English
• ISSNs: 0149-7634

Abstract

Highlights: Craving intensity is characterized by a dynamic temporal pattern. Biological and environmental factors modulate craving severity over time. A mechanistic comprehension of these factors would lead to new effective treatments. To take cognizance of these factors is key for relapse prevention. Abstract: It was suggested in 1986 that cue-induced cocaine craving increases progressively during early abstinence and remains high during extended periods of time. Clinical evidence now supports this hypothesis and that this increase is not specific to cocaine but rather generalize across several drugs of abuse. Investigators have identified an analogous incubation phenomenon in rodents, in which time-dependent increases in cue-induced drug seeking are observed after abstinence from intravenous drug or palatable food self-administration. Incubation of craving is susceptible to variation in magnitude as a function of biological and/or the environmental circumstances surrounding the individual. During the last decade, the neurobiological correlates of the modulatory role of biological (sex, age, genetic factors) and environmental factors (environmental enrichment and physical exercise, sleep architecture, acute and chronic stress, abstinence reinforcement procedures) on incubation of drug craving has been investigated. In this review, we summarized the behavioral procedures adopted, the key underlying neurobiological correlates and clinical implications of these studies.