Folic acid functionalization for targeting self-assembled paclitaxel-based nanoparticles. Issue 54 (12th December 2022)

• Record Type: Journal Article
• Authors: Colombo, Eleonora; Coppini, Davide Andrea; Maculan, Simone; Seneci, Pierfausto; Santini, Benedetta; Testa, Filippo; Salvioni, Lucia; Vanacore, Giovanni Maria; Colombo, Miriam; Passarella, Daniele
• Is Part Of: RSC advances. Volume 12:Issue 54(2022)
• Page Start: 35484
• Page End: 35493
• Publication Date: 2022-12-12
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d2ra06306a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Self-assembled hetero-nanoparticles are obtained by mixing paclitaxel and folic acid conjugates. Abstract : Hetero-nanoparticles self-assembled from a conjugate bearing folic acid as the targeting agent, and another bearing paclitaxel as the active agent are reported. Hetero-nanoparticles containing varying percentages of folic acid conjugates are characterised, and their biological activity is determined.