Association of painful human immunodeficiency virus distal sensory polyneuropathy with aberrant expectation of pain relief: functional magnetic resonance imaging evidence. Issue 4 (30th October 2021)

• Record Type: Journal Article
• Authors: Strigo, Irina A; Keltner, John R; Ellis, Ronald J; Simmons, Alan N
• Is Part Of: Brain communications. Volume 3:Issue 4(2021)
• Publication Date: 2021-10-30
• Subjects: neuropathy -- imaging -- insula -- reward -- striatum; 616
• DOI: 10.1093/braincomms/fcab260
• Languages: English
• ISSNs: 2632-1297

Abstract

Abstract: Mechanisms underlying chronic neuropathic pain associated with HIV-associated distal sensory polyneuropathy are poorly understood, yet 40% of those with distal neuropathy (or 20% of all people with HIV) suffer from this debilitating condition. Central pain processing mechanisms are thought to contribute to the development of HIV neuropathic pain, yet studies investigating central mechanisms for HIV neuropathic pain are few. Considering the motivational nature of pain, we aimed to examine the degree to which expectation of pain onset and expectation of pain offset are altered in sixty-one male patients with HIV-related distal sensory polyneuropathy with ( N = 30) and without ( N = 31) chronic neuropathic pain. By contrasting painful (foot) and non-painful (hand) sites between those with and without neuropathic pain, we could identify unique neural structures that showed altered activation during expectation of pain offset or relief. Our results showed no evidence for peripheral mechanisms evidenced by lack of significant between group differences in thermo-sensation, subjective pain response or epidermal nerve fibre density. Likewise, we found no significant differences between groups in subjective or brain mechanisms underlying the expectation of pain onset. Conversely, we found significant interaction within right anterior insula during expectation of pain offset in our study in that individuals in the pain group compared to the no-pain group exhibited increased anterior insula activation on the painful compared to the non-painful site. Our findings are consistent with abnormal processing of expectation of pain offset or abnormal pain relief-related mechanisms potentially due to increased emotional distress regarding the experience of chronic endogenous pain. Abstract : Mechanisms underlying chronic neuropathic pain associated with HIV-associated distal sensory polyneuropathy are poorly understood. Using functional MRI, Strigo et al. show abnormal expectation of pain offset response in those who developed neuropathic pain potentially due to lack of pain relief regarding the experience of chronic endogenous pain. Graphical Abstract: