Speeding up eQTL scans in the BXD population using GPUs. Issue 12 (16th August 2021)

• Record Type: Journal Article
• Authors: Trotter, Chelsea; Kim, Hyeonju; Farage, Gregory; Prins, Pjotr; Williams, Robert W; Broman, Karl W; Sen, Śaunak
• Is Part Of: G3. Volume 11:Issue 12(2021)
• Publication Date: 2021-08-16
• Subjects: linear model -- genome scan -- BXD -- GPU; Genetics -- Research -- Periodicals; Genomics -- Periodicals; Genetics; Genomics; Genes; Genetics -- Research; Genomics; Electronic journals; Periodical; Periodicals; Fulltext; Internet Resources; Periodicals; 572.8
• DOI: 10.1093/g3journal/jkab254
• Languages: English
• ISSNs: 2160-1836

Abstract

Abstract: The BXD family of mouse strains are an important reference population for systems biology and genetics that have been fully sequenced and deeply phenotyped. To facilitate interactive use of genotype–phenotype relations using many massive omics data sets for this and other segregating populations, we have developed new algorithms and code that enable near-real-time whole-genome quantitative trait locus (QTL) scans for up to one million traits. By using easily parallelizable operations including matrix multiplication, vectorized operations, and element-wise operations, our method is more than 700 times faster than a R/qtl linear model genome scan using 16 threads. We used parallelization of different CPU threads as well as GPUs. We found that the speed advantage of GPUs is dependent on problem size and shape (the number of cases, number of genotypes, and number of traits). Our approach is ideal for interactive web services, such as GeneNetwork.org that need to display results in real-time. Our implementation is available as the Julia language package LiteQTL at https://github.com/senresearch/LiteQTL.jl .