Toward Molecular Imaging of Intestinal Pathology. Issue 10 (14th August 2020)

• Record Type: Journal Article
• Authors: Le Fur, Mariane; Zhou, Iris Y; Catalano, Onofrio; Caravan, Peter
• Is Part Of: Inflammatory bowel diseases. Volume 26:Issue 10(2020)
• Page Start: 1470
• Page End: 1484
• Publication Date: 2020-08-14
• Subjects: inflammatory bowel disease -- molecular imaging -- noninvasive imaging -- intestinal fibrosis -- MRI -- PET -- SPECT -- US; Inflammatory bowel diseases -- Periodicals; Colitis, Ulcerative -- Periodicals; Crohn Disease -- Periodicals; Inflammatory Bowel Diseases -- Periodicals; 616.344
• DOI: 10.1093/ibd/izaa213
• Languages: English
• ISSNs: 1078-0998

Abstract

Abstract: Inflammatory bowel disease (IBD) is defined by a chronic relapsing and remitting inflammation of the gastrointestinal tract, with intestinal fibrosis being a major complication. The etiology of IBD remains unknown, but it is thought to arise from a dysregulated and excessive immune response to gut luminal microbes triggered by genetic and environmental factors. To date, IBD has no cure, and treatments are currently directed at relieving symptoms and treating inflammation. The current diagnostic of IBD relies on endoscopy, which is invasive and does not provide information on the presence of extraluminal complications and molecular aspect of the disease. Cross-sectional imaging modalities such as computed tomography enterography (CTE), magnetic resonance enterography (MRE), positron emission tomography (PET), single photon emission computed tomography (SPECT), and hybrid modalities have demonstrated high accuracy for the diagnosis of IBD and can provide both functional and morphological information when combined with the use of molecular imaging probes. This review presents the state-of-the-art imaging techniques and molecular imaging approaches in the field of IBD and points out future directions that could help improve our understanding of IBD pathological processes, along with the development of efficient treatments. Abstract : This review presents the state-of-the-art imaging techniques and molecular imaging approaches in the field of IBD and points out future directions that could help improve our understanding of IBD pathological processes, along with the development of efficient treatments.