Current safety concerns about the use of antiseizure medications in pregnancy. Issue 12 (2nd December 2022)

• Record Type: Journal Article
• Authors: Falcicchio, Giovanni; Russo, Emilio; Fabiano, Antonio; Scalese, Micaela; Boero, Giovanni; Trojano, Maria; de Tommaso, Marina; La Neve, Angela
• Is Part Of: Expert opinion on drug safety. Volume 21:Issue 12(2022)
• Page Start: 1459
• Page End: 1468
• Publication Date: 2022-12-02
• Subjects: Antiseizure medications -- pregnancy registries -- teratogenicity -- therapeutic drug monitoring -- women with epilepsy -- valproate; Drugs -- Side effects -- Periodicals; Drugs -- Toxicology -- Periodicals; Chemotherapy -- Periodicals; 615.704
• DOI: 10.1080/14740338.2022.2160443
• Languages: English
• ISSNs: 1474-0338

Abstract

ABSTRACT: Introduction: Given the high prevalence of epilepsy in women of childbearing potential (15 million out of 50 million people worldwide), antiseizure medication (ASM) use in pregnancy is common. Identifying the safest and most effective ASM to use during pregnancy is often difficult, but also crucially important. The challenge is to balance two needs: maintaining seizure control while minimizing teratogenicity. Areas covered: This review looks at seizure- and treatment-related risks to mother and fetus during pregnancy, existing healthcare information programmes, strengths and pitfalls of the main pregnancy registries, known and supposed pharmacokinetic changes during gestation, the utility of therapeutic drug monitoring, and safety concerns. Articles and related content were screened on available publications after January 2000. Expert opinion: The use of newer ASMs during pregnancy is still limited, as shown by the paucity of data collected by different pregnancy registries. Choosing these medications can be challenging, partly due to unknown pharmacokinetic modifications in pregnancy, an aspect that serum drug monitoring might help to clarify. The safest treatment is chosen also taking into account the woman's needs, concerns and wishes, but adequate pre-pregnancy counseling is necessary to properly inform her about personal and fetal risks related both to seizures and to medications.