Secretor and Salivary ABO Blood Group Antigen Status Predict Rotavirus Vaccine Take in Infants. (18th January 2017)

• Record Type: Journal Article
• Authors: Kazi, Abdul Momin; Cortese, Margaret M.; Yu, Ying; Lopman, Benjamin; Morrow, Ardythe L.; Fleming, Jessica A.; McNeal, Monica M.; Steele, A. Duncan; Parashar, Umesh D.; Zaidi, Anita K. M.; Ali, Asad
• Is Part Of: Journal of infectious diseases. Volume 215:Number 5(2017:Mar. 01)
• Page Start: 786
• Page End: 789
• Publication Date: 2017-01-18
• Subjects: Secretor -- rotavirus -- vaccine -- infants -- blood group -- FUT2 -- Lewis antigen.; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jix028
• Languages: English
• ISSNs: 0022-1899

Abstract

Summary: Histo-blood group antigens (HBGAs) expressed on enterocytes are proposed receptors for rotaviruses and measurable in saliva. Among Pakistani infants in a G1P[8] rotavirus vaccine trial, anti–rotavirus immunoglobulin A seroconversion rates after 3 vaccine doses differed significantly by HBGA phenotype. Abstract: Histo-blood group antigens (HBGAs) expressed on enterocytes are proposed receptors for rotaviruses and can be measured in saliva. Among 181 Pakistani infants in a G1P[8] rotavirus vaccine trial who were seronegative at baseline, anti–rotavirus immunoglobulin A seroconversion rates after 3 vaccine doses differed significantly by salivary HBGA phenotype, with the lowest rate (19%) among infants who were nonsecretors (ie, who did not express the carbohydrate synthesized by FUT2), an intermediate rate (30%) among secretors with non–blood group O, and the highest rate (51%) among secretors with O blood group. Differences in HBGA expression may be responsible for some of the discrepancy in the level of protection detected for the current rotavirus vaccines in low-income versus high-income settings.