Association of Macrophage Inflammation Biomarkers With Progression of Subclinical Carotid Artery Atherosclerosis in HIV-Infected Women and Men. (12th February 2017)

• Record Type: Journal Article
• Authors: Hanna, David B.; Lin, Juan; Post, Wendy S.; Hodis, Howard N.; Xue, Xiaonan; Anastos, Kathryn; Cohen, Mardge H.; Gange, Stephen J.; Haberlen, Sabina A.; Heath, Sonya L.; Lazar, Jason M.; Liu, Chenglong; Mack, Wendy J.; Ofotokun, Igho; Palella, Frank J.; Tien, Phyllis C.; Witt, Mallory D.; Landay, Alan L.; Kingsley, Lawrence A.; Tracy, Russell P.; Kaplan, Robert C.
• Is Part Of: Journal of infectious diseases. Volume 215:Number 9(2017:May 01)
• Page Start: 1352
• Page End: 1361
• Publication Date: 2017-02-12
• Subjects: atherosclerosis -- galectin-3 -- galectin-3 binding protein -- HIV infection -- inflammation -- intima-media thickness -- macrophages -- monocytes -- soluble CD14 -- soluble CD163.; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jix082
• Languages: English
• ISSNs: 0022-1899

Abstract

Summary: Serum sCD14 and sCD163 levels were associated with progression of carotid atherosclerosis over 7 years in the Women's Interagency HIV Study and Multicenter AIDS Cohort Study. These markers of macrophage-related inflammation may play important roles in atherogenesis among HIV+ persons. Abstract: Background: Monocytes and monocyte-derived macrophages promote atherosclerosis through increased inflammation and vascular remodeling. This may be especially true in chronic human immunodeficiency virus (HIV) infection. Methods: We examined 778 women (74% HIV + ) in the Women's Interagency HIV Study and 503 men (65% HIV + ) in the Multicenter AIDS Cohort Study who underwent repeated B-mode carotid artery ultrasound imaging in 2004–2013. We assessed baseline associations of the serum macrophage inflammation markers soluble (s)CD163, sCD14, galectin-3 (Gal-3), and Gal-3 binding protein (Gal-3BP) with carotid plaque formation (focal intima-media thickness >1.5 mm) over 7 years. Results: Marker levels were higher in HIV + persons versus HIV – persons. Presence of focal plaque increased over time: from 8% to 15% in women, and 24% to 34% in men. After adjustment for demographic, behavioral, and cardiometabolic factors, and CRP and interleukin-6, each standard deviation increase in sCD14 was associated with increased plaque formation (risk ratio [RR] 1.24, 95% confidence interval [CI] 1.07–1.43). This pattern was consistentby sex. sCD163 was associated with plaque formation in virally suppressed HIV + men (RR 1.52, 95% CI 1.04–2.22); Gal-3BP and Gal-3 were not associated with increased plaque. Conclusions: sCD14 and sCD163 may play important roles in atherogenesis among HIV + persons.