A "turn on" fluorometric and colorimetric probe based on vinylphenol-BODIPY for selective detection of Au(III) ion in solution and in living cells. (July 2021)

• Record Type: Journal Article
• Authors: Jantra, Suthikorn; Palaga, Tanapat; Rashatasakhon, Paitoon; Sukwattanasinitt, Mongkol; Wacharasindhu, Sumrit
• Is Part Of: Dyes and pigments. Volume 191(2021)
• Publication Date: 2021-07
• Subjects: BODIPY -- Gold -- Sensor -- Oxidation; Dyes and dyeing -- Periodicals; Pigments -- Periodicals; 667.2
• DOI: 10.1016/j.dyepig.2021.109341
• Languages: English
• ISSNs: 0143-7208

Abstract

Abstract: In this work, borondipyrromethene (BODIPY)-based fluorescent and colorimetric probe SBP has been explored as a sensor for selective detection of Au 3+ . The probe SBP containing two vinyl phenol groups at C3 and C5 position on BODIPY pyrrole rings is prepared to extend its emission wavelength into the red region (656 nm) and also to serve as a new receptor toward Au 3+ . The probe displayed colorimetric change from blue to pink and fluorometric change from red to orange (up to 40-fold at 590 nm) in aqueous medium, with the detection limit of 0.0094 μM. This colorimetric and fluorometric changes are caused by the oxidation of the double bond in the SBP facilitating by hydroxy group which is confirmed by detected intermediates from mass spectroscopy experiment. In addition, the "turn on" SBP probe is successfully applied for monitoring intracellular Au 3+ in living RAW264.7 macrophages through fluorescence imaging. Graphical abstract: Image 1 Highlights: A novel BODIPY-based probe SBP for gold(III) detection has been prepared. The probe detection mechanism is based on oxidation of styryl groups. The probe displayed colorimetric and fluorometric change selectively to Au 3+ ion. In vivo fluorescence imaging of Au 3+ in RAW264.7 macrophages with SBP is observed.