Analgesic use and the risk of renal cell carcinoma – Findings from the Consortium for the Investigation of Renal Malignancies (CONFIRM) study. (December 2021)

• Record Type: Journal Article
• Authors: Bruinsma, F.J.; Jordan, S.; Bassett, J.K.; Severi, G.; MacInnis, R.J.; Walsh, J.; Aitken, T.; Jenkins, M.; Carroll, R.; Jefford, M.; Davis, I.D.; Tucker, K.; Dudding-Byth, T.; English, D.R.; Giles, G.G.; Winship, I.; Milne, R.L.
• Is Part Of: Cancer epidemiology. Volume 75(2021)
• Publication Date: 2021-12
• Subjects: CONFIRM CONsortium for the investigation of Renal Malignancies -- HREC Human Research Ethics Committee -- OR odds ratio -- CI confidence interval -- RCC renal cell carcinoma -- NSAID non-steroidal anti-inflammatory drug; Renal cell carcinoma -- Epidemiology -- Analgesic use -- NSAIDs -- Paracetamol; Cancer -- Epidemiology -- Periodicals; Cancer -- Prevention -- Periodicals; Cancer -- Diagnosis -- Periodicals; Carcinogenesis -- Periodicals; 616.994005
• DOI: 10.1016/j.canep.2021.102036
• Languages: English
• ISSNs: 1877-7821

Abstract

Abstract: Purpose: The incidence of renal cell carcinoma (RCC) is rising. Use of analgesics such as non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol may affect renal function. The aim of this study was to assess associations between analgesic use and risk of RCC. Methods: A population-based case-control family design was used. Cases were recruited via two Australian state cancer registries. Controls were siblings or partners of cases. Analgesic use was captured by self-completed questionnaire. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for RCC risk associated with regular analgesic use (at least 5 times per month for 6 months or more) and duration and frequency of use. Results: The analysis included 1064 cases and 724 controls. Regular use of paracetamol was associated with an increased risk of RCC (OR 1.41, 95%CI 1.13–1.77). Regular use of NSAIDs was associated with increased risk of RCC for women (OR 1.71, 95% CI 1.23–2.39) but not men (OR 0.83, 95% CI 0.58–1.18; p-interaction=0.003). There was no evidence of a dose-response for duration of use of paracetamol (linear trend p = 0.77) and weak evidence for non- aspirin NSAID use by women (linear trend p = 0.054). Conclusion: This study found that regular use of paracetamol was associated with increased risk of RCC. NSAID use was associated with increased risk only for women. Highlights: Based on findings from a large, population-based case-control study, regular use of paracetamol was associated with an increased risk of renal cell carcinoma. A unique finding of this study was that regular non-steroidal anti-inflammatory drug usage was associated with an increased risk of renal cell carcinoma among women but not men.