A stochastic model for the normal tissue complication probability (NTCP) and applications. (1st September 2016)

• Record Type: Journal Article
• Authors: Stocks, Theresa; Hillen, Thomas; Gong, Jiafen; Burger, Martin
• Is Part Of: Mathematical medicine and biology. Volume 34:Number 4(2017:Dec.)
• Page Start: 469
• Page End: 492
• Publication Date: 2016-09-01
• Subjects: normal tissue complication probability -- logistic birth death process -- tumour control probability -- radiation treatment -- side effects -- TCP -- NTCP -- brachytherapy -- prostate cancer; Biomathematics -- Periodicals; Medicine -- Mathematics -- Periodicals; Medicine -- Periodicals; Biology -- Periodicals; Biomedical Research -- Periodicals; Models, Theoretical -- Periodicals; 570.15195
• DOI: 10.1093/imammb/dqw013
• Languages: English
• ISSNs: 1477-8599

Abstract

Abstract: The normal tissue complication probability (NTCP) is a measure for the estimated side effects of a given radiation treatment schedule. Here we use a stochastic logistic birth–death process to define an organ-specific and patient-specific NTCP. We emphasize an asymptotic simplification which relates the NTCP to the solution of a logistic differential equation. This framework is based on simple modelling assumptions and it prepares a framework for the use of the NTCP model in clinical practice. As example, we consider side effects of prostate cancer brachytherapy such as increase in urinal frequency, urinal retention and acute rectal dysfunction.