Deformed wing virus infection affects the neurological function of Apis mellifera by altering extracellular adenosine signaling. (December 2021)

• Record Type: Journal Article
• Authors: Chen, Ping; Lu, Yun-Heng; Lin, Yu-Hsien; Wu, Carol-P; Tang, Cheng-Kang; Wei, Sung-Chan; Wu, Yueh-Lung
• Is Part Of: Insect biochemistry and molecular biology. Volume 139(2021)
• Publication Date: 2021-12
• Subjects: Deformed wing virus (DWV) -- Honeybee (Apis mellifera) -- Adenosine -- Long-term memory; Insect biochemistry -- Periodicals; Insects -- Physiology -- Periodicals; Insects -- Molecular aspects -- Periodicals; Biochemistry -- Periodicals; Insectes -- Biochimie -- Périodiques; Insectes -- Composition -- Périodiques; Insectes -- Physiologie -- Périodiques; Insectes -- Aspect moléculaire -- Périodiques; Biochimie -- Périodiques; Biochemistry; Insect biochemistry; Insects -- Molecular aspects; Insects -- Physiology; Periodicals; 572.8157
• DOI: 10.1016/j.ibmb.2021.103674
• Languages: English
• ISSNs: 0965-1748

Abstract

Abstract: Deformed wing virus (DWV) infection is believed to be closely associated with colony losses of honeybee ( Apis mellifera ) due to reduced learning and memory of infected bees. The adenosine (Ado) pathway is important for maintaining immunity and memory function in animals, and it enhances antivirus responses by regulating carbohydrate metabolism in insects. Nevertheless, its effect on the memory of invertebrates is not yet clear. This study investigated how the Ado pathway regulates energy metabolism and memory in honeybees following DWV infection. Decreased Ado receptor (Ado-R) expression in the brain of infected bees resulted in a carbohydrate imbalance as well as impairments of glutamate-glutamine (Glu-Gln) cycle and long-term memory. Dietary supplementation with Ado not only increased the brain energy metabolism but also rescued long-term memory loss by upregulating the expression of memory-related genes. The present study demonstrated the regulation of the Ado pathway upon DWV infection and provides insights into the mechanisms underlying energy regulation and the neurological function of honeybees. Graphical abstract: Image 1 Highlights: Deformed wing virus reduces both learning ability and memory in honeybees. Extracellular adenosine (Ado) plays a critical role in supplying energy for neurotransmission in the honeybee brain. Our study provides new insights into the association between the Ado pathway and memory function in insects.