Assessment of the relationship between the hepatic contrast enhancement effect in the hepatobiliary phase and hepatic signal changes in free-breathing continuous multiphasic dynamic EOB-MRI. Issue 144 (November 2021)

• Record Type: Journal Article
• Authors: Tanabe, Masaya; Tanabe, Masahiro; Furukawa, Matakazu; Iida, Etsushi; Okada, Munemasa; Ito, Katsuyoshi
• Is Part Of: European journal of radiology. Issue 144(2021)
• Publication Date: 2021-11
• Subjects: Liver -- Free-breathing -- Multiphasic dynamic MRI -- EOB -- Compressed sensing; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2021.109959
• Languages: English
• ISSNs: 0720-048X

Abstract

Highlights: Free-breathing dynamic liver EOB-MRI was carried out by using compressed sensing. Enhancement ratio in arterio-portal phase was associated with hepatobiliary phase. Enhancement ratio in early hepatocyte phase was also associated. Sufficient enhancement in hepatobiliary phase may be estimated in these phases. Abstract: Purpose: To investigate the relationship between the hepatic contrast enhancement effect in the hepatobiliary phase (HBP) and the contrast enhancement parameters based on the data of continuous signal changes in free-breathing multiphasic dynamic EOB-MR imaging using a compressed sensing (CS) and the self-gating technique, and to clarify which contrast enhancement parameters are useful for estimating the hepatic enhancement effect in the HPB. Method: This study included 96 patients. The contrast enhancement ratio (CER) of the liver parenchyma from phase x to phase y was calculated as follows: CERy-x : (SIy -SIx )/SIx . The gradient of the regression line (GRL) was also calculated. Patients can be divided into two groups with sufficient or insufficient liver enhancement in the HBP, then each parameter was compared between these two groups. Results: In the analysis of the arterioportal phases, CER7-pre in the sufficient HBP enhancement group was significantly higher than that in the insufficient HBP enhancement group (0.50 vs 0.44, p < 0.001). Regarding 5 min early hepatocyte phase (phases 1–28) analysis, significant differences were observed in CER28-pre, CER28-7 and Gradient28-7 between the two groups (0.64 vs 0.47, 0.10 vs 0.03, 1.27 vs 0.27, all p < 0.001). For the strength of correlation, CER7-pre, CER28-pre, CER28-7, and GRL28-7 had higher correlation coefficients, compared with the blood sampling data. Conclusion: CER in the arterio-portal phase and 5 min early hepatocyte phase had significant correlation with hepatic contrast enhancement effects in the 20 min HBP, suggesting that sufficient 20 min HBP enhancement may be estimated by the CER in the portal phase and 5 min early hepatocyte phase.